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KMID : 0352519830200010111
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Korea Univercity Medical Journal
1983 Volume.20 No. 1 p.111 ~ p.117
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Role of Sympathetic Nervous System in the Increase induced by Picrotoxin or Morphine of Plasma Corticosterone Level
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Oh Chang-Joon
Chun Boe-Gwun
Shin Man-Ryun
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Abstract
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Vale et al. and Long reported that adrenaline originated from adrenal medulla may increase ACTH liberation from pituitary gland.
In this paper, the role of sympathetic nervous system in the increase induced by picrotoxin or morphine of plasma corticosterone level was studied in male mice.
The results obtained were summarized as follows;
1. Spinal cord transection did not affect the normal plasma corticosterone level. But phenoxybenzamine (10㎎/㎏) slightly decreased it and dexamethasone (0.5㎎/㎏) markedly decreased it. And the dexamethasone-induced decrease was enhanced by phenoxybenzamine.
2. Picrotoxin (4.0㎎/㎏) and morphine (25㎎/㎏) markedly increased the normal plasma corticosterone level.
3. The picrotoxin-induced increase of plasma corticosterone level was affected by phenoxybenzamine pretreatment, but the morphine-induced increase of it was significantly enhanced by the pretreatment.
4. The picrotoxin-induced increase of plasma corticosterone level was slightly suppressed by spinal cord transection, but the morphine-induced increase of it was affected by the transection procedure.
5. The picrotoxin or morphine- induced increase of plasma corticosterone level was markedly suppressed by dexamethasone pretreatment and the suppressing effect of dexamethasone was enhanced by phenoxybenzamine.
This study suggests that the increase induced by picrotoxin of morphine of plasma corticos terone level may be modulated by sympathetic nervous system.
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